<SEQUENCE LISTING>

<110>    GREEN CROSS CORPORATION

<120>    Human antibodies specifically binding to the Hepatitis B virus surface
         antigen

<130>    PCA912082GCC

<150>    KR 2009-0130900
<151>    2009-12-24

<160>    45

<170>    KopatentIn 1.71

<210>    1
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of HB48-33, HB48-35 or HB48-59
         antibody


<400>    1
Gln Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Leu Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Trp Ile Asn Thr Tyr Ser Gly His Thr Asn Tyr Ala Arg Lys Phe
     50                  55                  60 

Arg Gly Arg Val Thr Met Thr Trp Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Val Pro Thr Trp Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    2
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-33 antibody


<400>    2
Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
  1               5                  10                  15 

Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val
             20                  25                  30 

His Trp Tyr Gln Gln Lys Thr Gly Gln Ala Pro Val Leu Val Val Tyr
         35                  40                  45 

Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
     50                  55                  60 

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105        


<210>    3
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-35 antibody


<400>    3
Glu Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Asn
             20                  25                  30 

Val Asn Trp Phe Gln Gln Glu Pro Gly Lys Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ser Val Tyr Pro Leu
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg
            100                 105            


<210>    4
<211>    114
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-59 antibody


<400>    4
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
             20                  25                  30 

Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Gln Leu Leu Ile Tyr Leu Gly Ser Lys Arg Ala Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Gln Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
                 85                  90                  95 

Thr Gln Phe Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys Arg
       


<210>    5
<211>    351
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of HB48-33, HB48-35 or HB48-59
         antibody


<400>    5
caggtgcagc tggtgcagtc tgggggtgag gtgaagaagc ctggggcctt aatgaaggtc         60

tcctgcaagg cttctggtta catctttacc agttatggta tcagctgggt gcgacaggcc        120

cctggacaag ggcttgagtg gataggatgg atcaacactt acagtggtca cacaaactat        180

gcacggaagt tccgggggag agtcaccatg acctgggaca cgtccaccag cacagcctac        240

atggagctga gcagcctgag atctgacgac acggccgtct attactgtgc gagagtccca        300

acgtggggta ttgactactg gggccaggga accctggtca ccgtctcctc a                 351


<210>    6
<211>    321
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-33 antibody


<400>    6
caggcagggc tgactcagcc accctcagtg tcagtggccc caggaaagac ggcccggatt         60

acctgtgggg gagacaacat tggaagaaaa agtgtgcact ggtaccagca gaagacaggc        120

caggcccctg tgctggtcgt ctatgaagat aacaagcggc cctcagggat acctgagcga        180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg        240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg        300

accaagctga ccgtcctagg t                                                  321


<210>    7
<211>    324
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-35 antibody


<400>    7
gaaattgtgt tgacgcagtc tccaccctcc ctgtctgcat ctgtaggaga cagagtcacc         60

atcacttgcc aggcgagtca ggacattaat aacaatgtaa attggtttca gcaggaacca        120

gggaaagccc ctaggctcct gatctacgat gcatccaatt tgcaaacagg ggtcccatca        180

aggttcagtg gaagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct        240

gaagattttg caacttatta ctgtcaacag actagtgttt accctctcac tttcggcgga        300

gggaccaagg tggatatcaa acgt                                               324


<210>    8
<211>    342
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of HB48-59 antibody


<400>    8
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc         60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg        120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taagcgggcc        180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagatttcac actgcaaatt        240

agtagagtgg aggctgagga tgttggggtt tattactgca tgcaatctac acaatttcca        300

ccgtacactt ttggccaggg gaccaagctg gagatcaaac gt                           342


<210>    9
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-forward primer


<400>    9
gttgttcctt tctatgcggc ccagccggcc atggcc                                   36


<210>    10
<211>    30
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-reverse primer for light chain variable kappa


<400>    10
gagtcattct cgacttgcgg ccgcacgttt                                          30


<210>    11
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-reverse primer for light chain variable lambda


<400>    11
gagtcattct cgacttgcgg ccgcacc                                             27


<210>    12
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH1-forward primer


<400>    12
cagccggcca tggcccaggt gcagctggtg cagtctggg                                39


<210>    13
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH2-forward primer


<400>    13
cagccggcca tggcccagrt caccttgaag gagtctggt                                39


<210>    14
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH3-forward primer


<400>    14
cagccggcca tggccsaggt gcagctggtg gagtctggg                                39


<210>    15
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH4-forward primer


<400>    15
cagccggcca tggcccaggt gcagctgcag gagtcgggc                                39


<210>    16
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH5-forward primer


<400>    16
cagccggcca tggccgaggt gcagctggtg cagtctgga                                39


<210>    17
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH6-forward primer


<400>    17
cagccggcca tggcccaggt acagctgcag cagtcaggt                                39


<210>    18
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH7-forward primer


<400>    18
cagccggcca tggcccaggt gcagctggtg caatctgag                                39


<210>    19
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH-reverse primer


<400>    19
cgatccgcca cctccggagc cacctccgcc tgaaccgcct ccacc                         45


<210>    20
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK1/3A-forward primer


<400>    20
ggtggctccg gaggtggcgg atcggacatc cagatgaccc agtctcca                      48


<210>    21
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK1/3B-forward primer


<400>    21
ggtggctccg gaggtggcgg atcggaaatt gtgttgacgc agtctcca                      48


<210>    22
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK2-forward primer


<400>    22
ggtggctccg gaggtggcgg atcggatatt gtgatgaccc agactccact c                  51


<210>    23
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK4-forward primer


<400>    23
ggtggctccg gaggtggcgg atcggacatc gtgatgaccc agtctcca                      48


<210>    24
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK5-forward primer


<400>    24
ggtggctccg gaggtggcgg atcggaaacg acactcacgc agtctcca                      48


<210>    25
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK6-forward primer


<400>    25
ggtggctccg gaggtggcgg atcggawrtt gtgmtgactc agtctcca                      48


<210>    26
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Jk-A-reverse primer


<400>    26
tcgacttgcg gccgcacgtt tgatwtccac yttggtccc                                39


<210>    27
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JK-B-reverse primer


<400>    27
tcgacttgcg gccgcacgtt tgatctccas cttggtccc                                39


<210>    28
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JK-C-reverse primer


<400>    28
tcgacttgcg gccgcacgtt taatctccag tcgtgtccc                                39


<210>    29
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL1~3-A-forward primer


<400>    29
ggtggctccg gaggtggcgg atcgcagtct gysctgactc agccaccc                      48


<210>    30
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL1~3-B-forward primer


<400>    30
ggtggctccg gaggtggcgg atcgtcctat gagctgacwc agccaccc                      48


<210>    31
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL4-forward primer


<400>    31
ggtggctccg gaggtggcgg atcgcwgcyt gtgctgactc agycvycs                      48


<210>    32
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL5-forward primer


<400>    32
ggtggctccg gaggtggcgg atcgcagsct gtgctgactc agccabct                      48


<210>    33
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL6-forward primer


<400>    33
ggtggctccg gaggtggcgg atcgaatttt atgctgactc agccccac                      48


<210>    34
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL7-forward primer


<400>    34
ggtggctccg gaggtggcgg atcgcagrct gtgactcagg agccctca                      48


<210>    35
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL8-forward primer


<400>    35
ggtggctccg gaggtggcgg atcgcagact gtggtgaccc aggagcca                      48


<210>    36
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL9-forward primer


<400>    36
ggtggctccg gaggtggcgg atcgcagcct gtgctgactc agccacct                      48


<210>    37
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL10-forward primer


<400>    37
ggtggctccg gaggtggcgg atcgcaggca gggctgactc agccaccc                      48


<210>    38
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JL-A-reverse primer


<400>    38
ttctcgactt gcggccgcac ctaggacggt sascttggtc cc                            42


<210>    39
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JL-B-reverse primer


<400>    39
ttctcgactt gcggccgcac cgaggacggt cagctgggtg cc                            42


<210>    40
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    P033 (scFv sequencing primer)


<400>    40
caacgtgaaa aaattattat tcgc                                                24


<210>    41
<211>    60
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Forward primer for PCR of heavy chain variable region


<400>    41
ggagacccaa gcttggtacc gagctcggat ccactagtaa cggccgccag tgtgctggaa         60

                                                                          60


<210>    42
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Reverse primer for PCR of heavy chain variable region


<400>    42
gaagaccgat gggcccttgg tggaggctga ggagacggtg ac                            42


<210>    43
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Forward primer for PCR of light chain (kappa & lambda)


<400>    43
tagggagacc cgctagcgga gcaagatgga ttcacaggcc caggt                         45


<210>    44
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Reverse primer for PCR of light chain (kappa)


<400>    44
tatagaatag ggccccccct cgaggtcgac ctaacactct cccct                         45


<210>    45
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Reverse primer for PCR of light chain (lambda)


<400>    45
atagaatagg gccccccctc gaggtcgaca tgaacattct gtaggggcca c                  51


